This study aims to understand the teaching challenges and needs of special education teachers when they educate the students with multiple/severe disabilities and complex health care needs at self-contained classrooms in elementary schools. Participants were five self-contained special education teachers in New Taipei City. Qualitative data were collected via focus group interviews, and analyzed using inductive coding approach. The consistency in coding between the researcher and peer reviewer are 83-100%. The results are as follows: A. The challenges as below: (1) The system of the schools could not provide professional health and medical care to the students. (2) The students have poor academic performance, so the teachers will feel frustrated in this kind of ineffective teaching. (3) The current administrative system could not provide health and medical care supports properly to the teachers. (4) The service hours of the collaborative teams could only provide rough solutions to the students. (5) Many parents overprotect their children that caused a number of conflicts between parents and teachers. B. The needs as below: (1) The government provides additional funding to improve equipment and compile books providing instruction on how to educate the students with multiple and severe disabilities. (2) Increase more opportunities for teachers to pursue further knowledge about teaching and caring the students. (3) The school administration actively shoulder the responsibility of caring the students together with the teachers. (4) The government should establish professional medical collaborative teams.