This article explores a 58-year-old woman’s nursing care experience with renal glomerulonephritis caused by lupus erythematosus. The period of nursing care was from January 20 to February 1, in 2017. Using the Gordon’s 11 healthy functional modalities for evaluation, the author collected data by direct care, observation, interviews, collecting medical history and reviewing medical records, and thus identified three major nursing problems as follows: fluid volume overload, high risk of infection and anxiety. During care, daily input volume and output volume and body weight were recorded to maintain the body fluid volume balance; we observed the presence or absence of redness, swelling, fever, and pain in the catheter wound to reduce infection; and taught cases and family members progressive muscle relaxation techniques and promoted disease related knowledge to alleviate anxiety and uncertainty about the disease. Through a good nursing-patient relationship, the author took the initiative to care about and listen to the inner anxiety of the patient. Through cross-team cooperation, we provided correct disease information and prognosis, assisted patients to develop a positive attitude to face the disease and treatment and facilitated self-care after subsequent discharge, thereby improving the quality of care.