De Architectura, or Ten Books on Architecture, written by the Roman architect Marcus Vitruvius Pollio in the 1st century BCE is the only treatise on architecture of the Classical Period that survived into the present day. Many ideas mentioned in this treatise have been continuously exerting considerable influence on the theory and practice of architecture from the Renaissance to the present. However, some topics in De Architectura seem to have attracted less academic attention for a long time, such as the ideas of the Four-element and Four-quality systems. The two systems originating in ancient Greek philosophy and medicine were applied to the field of architecture for the first time in De Architectura. The so-called Four Elements are air, fire, water and earth, and the Four Qualities are cold, hot, dry and wet. In the period of Classical Greece, the correspondence between the two systems were established; air is hot and wet, fire hot and dry, water cold and wet, and earth cold and dry. According to such a correspondence, the theory about the transformation between the Four Elements are also established. This paper mainly aims to explore the role of the Four-element and Four-quality systems in De Architectura, examining how the ideas of the two systems were used to elaborate the common principles of human body, nature and architecture, and formed the basis of a variety of architectural theories, especially those about building materials, architectural design and urban planning. The description related to the two systems in De Architectura can be found in several books of this treatise, including Book I, II, V, VI and VIII. This paper also undertakes to clarify whether the ideas in De Architectura were derived from the theories of certain ancient Greek philosophers and medical scholar. Moreover, according to a preliminary comparison with the Wu-Xing System in Chinese Feng-Shui and the Pancha-Bhuta System in Indian Vāstu-Shāstra, an attempt is also made to discuss whether different classical-element systems may possibly have certain common characteristics andmeaning in different traditions of architectural theories.