Anterior Segment-Optical coherence tomography (AS-OCT) was performed on an 80-year-old woman with a history of Herpes Zoster Ophthalmicus on her right eye. Cross-section image showed opacity and stromal keratitis mainly in the anterior half of stroma. From the AS-OCT pachymetry map, an overall thinning of cornea was observed on the region within immune ring. By examining both pachymetry map and epithelium map, thickening of the epithelium and thinning of stroma at the ring site were found, resulting in a smoother cornea. With the aid of AS-OCT, the ultra-structure of the cornea in patients of Herpes Zoster Ophthalmicus could now be visualized layer by layer and in turn assist diagnosis.