Skin pruritus is an inevitable nightmare for many uremic patients, as it is subjectively felt and easily overlooked by medical staff. For long-term sufferers, the itching not only affects social activities, but also the quality of life. Therefore, how to properly perform the clinical assessment and management of skin pruritus is very important. Only by improving the medical staff’s awareness of the symptoms and mechanism can appropriate treatment be provided early to relieve the patient’s physical, mental and social discomfort caused by skin pruritus. It is hoped that by collecting the itching-related pathogenesis, evaluation methods and clinical treatments in this article, the latest information and empirical experience will be helpful to the clinical application of medical staff, and work together to improve the quality of life of uremic patients.