Fusion in the lumbosacral spine is a common surgical procedure for management of a variety of spinal pathologies. Transpedicular screw fixation is the most commonly used technique for posterior lumbar fusion surgery. However, the traditional transpedicular path can become blocked by bone cement, which is frequently used to treat osteoportic compression fractures. Therefore, we introduced the cortical bone trajectory (CBT) with bone cement as an alternative fixation option for treating patients with previously augmented vertebrae. An 87-year-old woman presented with lower back pain with radiation to the left leg after a fall 2 months prior to presentation. She had undergone vertebroplasty at the L3 osteoportic vertebra and discectomies in the L3-4 and L4-5 vertebrae 2 years before admission. Progressive spondylolisthesis and recurrent discs with nerve root compression in previous surgical levels were diagnosed based on magnetic resonance images. The patient underwent transforaminal lumbar interbody fusion in L3-4 and L4-5 and screw fixation from L3 to L5 using CBT with bone cement. During surgery, CBT was approached under fluoroscopy. Because of the osteoporotic vertebrae, 0.5 ml of polymethylmethacrylate cement was injected before insertion of each screw. No immediate cement leakage was observed. Postoperatively, the patient’s previous neurological deficits gradually recovered, and no displacement or loosening of instruments was observed 6 months after surgery. Our case demonstrated that CBT with bone cement is an alternative fixation option for osteoporotic patients with previously augmented vertebrae.