The main purpose of this article is to review the use of ultrasound-guided arterial catheterization by nurse practitioners to shorten the catheter insertion time, increase the success rate, and avoid related complications. Intra-arterial blood pressure measurement is more accurate than noninvasive blood pressure measurement. An arterial line is often used on critical patients for continuous blood pressure monitoring and frequent arterial blood sampling. Three common ways of inserting a peripheral arterial catheter are to catheter over the needle, over the wire, and by the guidance of ultrasound. Compared to other ways of arterial catheterization, ultrasound-guided catheterization has a better success rate and less complications by displaying images of relative anatomic position of peripheral arteries during insertion. This procedure can be legally done by nurse practitioners. Therefore, it is advisable for nurse practitioners to receive proper and standardized ultrasound training, and to perform the ultrasound guided peripheral arterial catheterization procedure extensively in their practice. This will be a new standard for applying technology by nurse practitioners and a new breakthrough in critical care.