Entrepreneurship is widely recognized as an important driver of innovation and economic development. The trend of design entrepreneurship has emerged globally and becoming a new career option for designers. It is observed that design enterprises are increasing in Taiwan. Since entrepreneurship is a vital driver of economic development, these design enterprises in Taiwan can serve as real cases to get insight of the approaches to design entrepreneurship. Hence, the method of case study was adopted. Ten design enterprises were selected as cases for the research. With value chain analysis, this study aims to investigate how design entrepreneurs integrate available resource and seize market opportunity to create value for their business. According to the results, three models of value-chain management were identified from this study: collaboration of design and production, alliance of design and distribution, and niche creativity. The findings are further discussed to provide a better understanding of the approaches to design entrepreneurship in Taiwan.