膠質母細胞瘤：小分子核糖核酸對甲基鳥嘌呤甲基轉移酶表現的調控作用

Glioblastoma Multiforme: The Role of MicroRNA in MGMT Expression Regulation

我們在此報告一個以低溫療法成功治療的新生兒案例，該新生兒因大量胎兒母體間輸血造成致命的嚴重貧血與周產期窒息。此新生兒於出生時便呈現周產期窒息、全身性低肌張力，嚴重低血壓、嚴重代謝性酸中毒、嚴重貧血（血紅素值為2.0克／公合）以及第二級的新生兒缺氧缺血性腦病變。低溫治療於是於新生兒出生後四小時開始使用，溫度設定於攝氏33度，總共持續72小時。母體血液的Kleihauer-Betke測驗為陽性，計算得胎兒失血致母體的血量約為240毫升。胎兒於產後第七天成功拔管，且其整體活力、肌張力與經口進食能力皆於復健治療後逐漸改善。聽力測驗顯示兩側聽力皆為正常，於四個月大時也無發展遲緩情形。

We report a neonate with life-threatening anemia and HIE caused by massive FMT who was successfully treated with therapeutic hypothermia. This newborn presented with birth asphyxia, general hypotonia, undetectable blood pressure, marked metabolic acidosis, profound anemia (hemoglobin = 2.0 g/dL), and stage 2 HIE. Therapeutic hypothermia with a target temperature of 33°C was initiated at the age of 4 h for a total of 72 h. A Kleihauer–Betke test of maternal blood was positive and the estimated blood loss from the fetus to the mother was approximately 240 mL. He was extubated on day 7, and the general activity, muscle tone, and oral feeding improved gradually. The hearing test revealed normal hearing bilaterally. Neuro- logical development at 4 months of age was not delayed. Therefore, therapeutic hypothermia should be a choice for the treatment of critical newborn infants with massive FMT complicated with HIE.