以低溫療法治療因大量胎兒母體間輸血所致之嚴重貧血與週產期窒息之新生兒案例報告

Therapeutic Hypothermia to Treat a Critical Neonate with Life-Threatening Anemia and Perinatal Asphyxia Caused by Massive Fetomaternal Transfusion

大量的胎兒母體間輸血會導致嚴重的胎兒貧血，進一步導致胎兒或新生兒休克與窒息，甚至造成新生兒死亡或缺氧缺血性腦病變。治療性低體溫可以延緩腦部軸突細胞的死亡，理論上對於周產期窒息與缺氧的新生兒具有神經保護作用。

Massive fetomaternal transfusion (FMT) causes serious anemia, induces fetal/neonatal shock and asphyxia, and increases the risk of death or hypoxic-ischemic encephalopathy (HIE) in the neonate. Therapeutic hypothermia delays anoxic brain cell damage by suppressing tis- sue inflammation, intracellular signaling, and programed cell death; thus, it is neuroprotective in the neonatal brain with perinatal asphyxia. Therapeutic hypothermia is currently the standard of care for neonates with HIE.