| 中文摘要 |
期刊連結：http://www.gouthyperuricemia.org
Objective: The aim of this study was to explore the clinical features and related risk factors of primary gout in the northeastern area of Sichuan.
Methods: A total of 583 subjects with gout and a cohort of 459 control subjects without gout were matched in terms of age and sex. Clinical parameters were recorded and routine biochemistry tests were conducted for both groups. Odds ratios (ORs) and 95% confidence intervals (CIs) for associations of risk factors with primary gout were utilized along with multiple logistic regression analysis.
Results: Among all the incident gout cases, only one joint was involved in the first attack in 94.9% of cases, while attacks involved the first metatarsophalangeal joint in 68.61% of cases. 364 (62.44%) patients had predisposing factors, 88.16% of which were related to dietary factors such as beer and seafood. The most common comorbidity was hyperlipidemia (66.90%), followed by hypertension (35.68%) and hypercholesterolemia (23.33%). Incidence of tophi was significantly correlated with the course of disease and the level of serum uric acid (all p<0.01). In addition, multiple logistic regression analysis revealed that the occurrence of primary gout was correlated with the following factors: hyperuricemia, alcohol use, BMI, hypertriglyceridemia, diet, hypertension and smoking (p<0.05).
Conclusion: We were able to demonstrate that the clinical manifestations of gout were heterogeneous. Hyperuricemia, alcohol intake, obesity, hypertriglyceridemia, purine-rich diets, hypertension and smoking were the most important risk factors for primary gout. However, further prospective studies are needed to investigate the specific pathogenesis between risk factors and primary gout. |
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