Amlodipine 中毒之處置:案例報告

Perioperative Nursing Experience of a Patient with Treatment of amlodipine intoxication: case report

鈣離子阻斷劑 (calcium channel blockers, CCBs) 常用於治療心血管疾病,然而,當這些藥品服用過量時,卻可能導致致命性的結果;Amlodipine 中毒並無專一性的解毒劑,且無法經由血液透析排除。本文報告一 51 歲男性,吞服了約250mg amlodipine 企圖自殺,之後發生嚴重低血壓以及休克的症狀,在加護病房以calcium chloride、norepinephrine 、和 dopamine 治療後,血壓有明顯的改善,血管昇壓劑在入院第 3 天時停用,在經過醫療處置與身心科會診之後,病患於入院 10天後出院。鈣離子阻斷劑中毒可能危及生命,給予強心劑、注射鈣鹽、和支持治療來維持血液動力學為最重要的處置。

Calcium channel blockers (CCBs) are prescribed in treating cardiovascular conditions. Nevertheless, they remain a major cause of cardiovascular drug overdose that may lead to a lethal outcome. There is no specific antidote for amlodipine overdose, and this drug cannot be removed by hemodialysis. We report a 51-year-old male who attempted suicide and took about 250mg amlodipine, then experienced severe hypotension and shock. The patient was treated with calcium chloride, norepinephrine and dopamine. A rise in blood pressure and heart rate were observed. Inotropic agents were tapered off at the 3rd day of admission. Following medical treatment and psychiatric consultation, the patient was discharged after 10 days of hospitalization. CCB intoxication may be a life-threatening condition, providing inotropic agents, intravenous calcium, and support care for maintaining hemodynamics is the most important treatment.