復發性困難梭狀芽孢桿菌之另類療法—糞菌群移植

Fecal Microbiota Transplantation: The Alternative Therapies for Recurrent Clostridium Difficile

困難梭狀芽孢桿菌（Clostridium difficile）感染是常見的院內感染性腹瀉。不論是在歐美國家或是台灣，困難梭狀芽孢桿菌感染的情形均逐漸增加，從2002年至2009 年，困難梭狀芽孢桿菌感染的發生率增長了230%。因其發病率上升、感染的難治性以及容易多次復發。目前困難梭狀芽孢桿菌感染性腸炎已經成為一個普遍的臨床問題，對於困難梭狀芽孢桿菌感染的治療，傳統上是以口服的硝基甲嘧唑乙醇（metronidazole）或萬古鰴素（vancomycin）為首選用藥，然而，其高復發率卻是治療的難處，常規治療通常無法獲得良好效果。現今對於【糞菌群移植】的研究顯示能提高困難梭狀芽孢桿菌感染的治癒，對於此類臨床患者的腹瀉改善效果優於藥物治療也趨於自然。藉由此文獻分析提供與各位先進分享。

Clostridium difficile is a common cause for nosocomial infectious diarrhea. The cases of infection with C. difficile were increased by 230% in most European and Asian countries from 2003 to 2009. The pseudomembranous colitis has become a common clinical issue due to the increased rate of incidence, difficulty of treatment and likelihood of recurrence. Although oral intake of Metronidazole or Vancomycin has served as the first traditional method of treatment for C. difficile, thehigh recurrence rate has been a drawback in clinical environments, and the regular treatments usually have not got well results. Nevertheless, the fecal microbiota transplantation has been proved to increase the cure rate for the infection of Clostridium difficile. It not only ismore effective than traditional treatments, but also has a high recovery rate and is a more natural method of treatment.