External-ventricular drainage (EVD) is a common procedure in neurosurgery. If the amount of drain-age could not be recorded accurately, it might affect the decisions on medical treatments and then negatively affect the patient’s progress. The goal of this project is to improve the completeness of nursing instruction for EVD care. Based on clinical observation, we found that each nurse had different knowledge and understanding of EVD. They were also lack of comprehensive training and suitable teaching tools and aids for delivering the nursing instruction for patients with EVD. Therefore, the strategies to improve the nursing instruction include drawing-up a flow chart of EVD care, establishing the standard of care, organizing in-service training for the nurses, providing the instruction sheets of EVD-care, developing multi-media teaching aid DVD, and creating a specific hanger for EVD. The integrity of nursing instruction for the patients with EVD increased from 64.6% to 91.1% after the execution of the above strategies. The results of this project could be used to improve the nursing quality of EVD care in neurosurgery department and ICU.