The objective of this article is to describe the nursing experiences accumulated from providing palliative care to a premature infant with severe persistent pulmonary hypertension. Adopting Gordon 11 functional health patterns as the mainframe of this assessment from 21/08/2011 to 11/09/2011, three main nursing diagnoses had been identified as follows: (1) Impaired gas exchange (2) Anticipatory grieving (3) Risk of impaired skin integrity. The nursing progress was consequently divided into three parts (1) the nurse assisted with using high-frequency oscillatory ventilation and nitric oxide therapy. Palliative care was applied to enhance the case’s comfort during the progression of disease. (2) To face the anticipatory grieving, initiative for consultation was taken to encourage parents to express feelings and problems at the same time the frequency of interviews increased as well as relevant medical resources provided. (3) Approaches such as providing water pillow, baby lotion or oil and increasing the frequency of positioning were all used to prevent the infant’s skin integrity damage. After this infant’s parents signed the Consent of No Resuscitate, this patient went to the end of life on 11/09/2011 without much suffering. By documenting this nursing experience, the author wishes to provide valuable knowledge associated with palliative care that will be considered by colleagues in nursing critical preterm infant.