This article described the nursing experience on a 62 year old male with terminal lung cancer, who suffered from death anxiety due to unpredictable disease process. The nursing period was between May 29, 2012 and June 15, 2012. Through methods of holistic assessment, observation and interview, we collected data from physical, mental, social and spiritual dimensions. We analyzed these data and summarized that this patient faced problems such as failure of cleaning function in respiratory tract, death anxiety, and the sadness family members because of awareness of the patient will be numbered. Based on Watson care theory, we managed the problem of failure of cleaning function in respiratory tract with corresponding nursing measures in the nursing process. These nursing measures included aerosol therapy to decrease sputum viscosity, encouraging the use of deep and slow abdominal breathing, and forceful coughing to facilitate sputum discharge. About facing death anxiety, we leaded the patient telling the true feelings inside through the nursing staff’s accompany and support. We also arranged family seminars, encouraged the patient speak out the unfinished wishes, and assisted family members to complete them as soon as possible. In addition, we provided the family members support systems for assistance in positive attitude to face the grieving process. We share this nursing experience and expect it as a reference for care of terminal-illed patients in the future.