Researching on susceptibility and function of SLC2A9 associated with uric acid: a systematic review

期刊連結：http://www.gouthyperuricemia.com

Purpose
Solute carrier family 2 member 9 (SLC2A9) is not only a hexose-transport facilitator but a urate transporter. This review provides an update on the susceptibility and function of SLC2A9 associated with uric acid, which will provide a better understanding of related diseases.
Findings
Variations in SLC2A9 were the most statistically significant genetic determinant of serum urate. Among loci reported, some show ethnic heterogeneity, while others share the same susceptibility in spite of crossing populations. Functionally, SLC2A9 is reported to be closely associated with many diseases by regulating uric acid homeostasis in the body, such as hyperuricemia and gout. Furthermore, SLC2A9 can maintain reactive oxygen species (ROS) homeostasis by adjusting uric acid level, thereby preventing accumulation of ROS-associated damage that potentially contributes to cancer development.
Conclusion
Single nucleotide polymorphisms (SNPs) in SLC2A9 were associated with serum uric acid. As a robust urate transporter, SLC2A9 contributes to the occurrence and development of hyperuricemia, gout and other diseases by regulating uric acid homeostasis.