This program aims to improve the ability of nurses to prevent patients' suicide. This research was motivated by two patients committed suicide in a unit between 2016 and 2018. After cause analysis, the possible causes include lack of suicide prevention related care experience and on-the-job education, unfamiliarity with suicide prevention procedures, and lack of assessment tools/skills, lack of guidelines for the placement of dangerous goods, assessment mechanisms for high-risk of suicide patients as well as assessment of emotional stress. The method was to establish a suicide risk assessment mechanism, provide suicide assessment reminder cards and suicide prevention posters, and organize educational training. The correct rate of suicide awareness of nurses increased from 53.8% to 92.9%; the complete rate of stress assessment of cancer patients increased from 67.1% to 99.4%; the implementation rate of suicide assessment increased from 15.4% to 82.7%; the guidance rate for ward placement of dangerous goods increased from 0% to 79.0%; confidence increased from 4.9 points to 9.2 points; and during the study period, no suicide cases occurred, suggesting favorable program outcome. Therefore, we recommend disseminating these strategies to other units to improve patient safety and to enhance the quality of care.