代謝症候群之臨床特徵與結腸直腸良性息肉之關係

Relationship Between the Clinical Characteristics of Metabolic Syndrome and Benign Colorectal Polyps

目的：本研究目的在評估代謝症候群及其組成因子與結腸直腸良性息肉之間的關係。方法：我們對2011年至2017年在高雄市某區域醫院接受大腸鏡檢查作為篩檢的對象進行研究，代謝症候群定義以衛生福利部2007年標準為定義，結腸直腸良性息肉定義為腸胃科醫師執行大腸鏡檢，結果經病理切片診斷確定為結腸直腸息肉者。結果：共收集有效樣本846人，結果發現有代謝症候群較沒有代謝症候群者，有較高比例罹患結腸直腸良性息肉（47.4％ vs. 33.4％）。有結腸直腸良性息肉者較沒有者在三酸甘油酯（45.5％ vs. 32.4％）、腰圍（44.2％ vs. 35.0％）、空腹血糖（47.3％ vs. 33.2％）均較高，且達統計顯著差異。男性結腸直腸良性息肉比例顯著高於女性，年齡越大者亦有相似的發現。經邏輯斯迴歸分析我們發現性別、年齡與三酸甘油酯是罹患良性結腸直腸息肉的危險因子。結論：男性、年齡≧41歲、高三酸甘油酯是罹患良性結腸直腸息肉的危險因子。

Purposes: The aim of this study was to evaluate the relationship between metabolic syndrome, its constituent factors, and benign colorectal polyps. Methods: Between 2011 and 2017, patients who underwent colonoscopy at a regional hospital in Kaohsiung City were screened and selected as participants for this study. Metabolic syndrome was defined in accordance with the 2007 Ministry of Health and Welfare guidelines. Benign colorectal polyps were screened via colonoscopy and confirmed by a gastroenterologist through pathology evaluation. Results: Collected a total of 846 valid samples, the results showed that there was a higher proportion of subjects with metabolic syndrome had benign colorectal polyps than those without metabolic syndrome (47.4% vs. 33.4%). Subjects with benign colorectal polyps had significantly higher triglyceride levels (45.5% vs. 32.4%), waist circumference (44.2% vs. 35.0%), and fasting blood glucose (47.3% vs. 33.2%) than those without benign colorectal polyps. Logistic regression analysis showed that gender, age, and triglyceride levels were risk factors for benign colorectal polyps. Benign colorectal polyps was more prevalent among men than women and among older adults than younger ones. Conclusions: In conclusion, subjects with metabolic syndrome and high triglyceride levels, waist circumference, and hyperglycemia were more likely to suffer from colorectal benign polyps. Male gender, age≧41 years old, and hypertriglyceridemia are risk factors for benign colorectal polyps.