外陰惡性黑色素瘤案例報告與文獻回顧

Vulvar malignant melanoma: a case report and literature review

外陰惡性黑色素瘤是罕見的婦女癌症，為外陰癌症中第二常見之細胞型別。五年存活率平均50到60％。一位64歲女性以停經後出血、外陰搔癢就醫發現外陰惡性黑色素瘤，接受根除性外陰切除合併雙側腹股溝淋巴結廓清手術。治療上以手術切除病兆為主。免疫檢查點抑制劑與標靶藥物已知對於上皮性惡性黑色素瘤有延後復發與改善存活率的效果，因此為未來重點發展藥物。

Vulvar malignant melanoma is a rare disease, and the second most common malignancy of vulvar malignancies. The reported 5-year overall survival rate for vulvar melanoma is in the range of 50% to 60%. A 64-year-old female presented with postmenopausal vulvar spotting and itching, which later was diagnoses as vulvar malignant melanoma. She received radical vulvectomy and bilateral inguinal lymph node dissection. The primary treatment for vulvar malignant melanoma is surgical resection. Immune checkpoint inhibitors and targeted therapy have proved to improve progression free survival and overall survival of cutaneous melanoma. Future studies on vulvar malignant melanoma are necessary.