Physical assessment is one of the important clinical competences for nursing students to obtain during school years. Cultivating students with respect and caring attitude is also important during the process of nurse education. This paper demonstrates the effects of patient-centered and caring-oriented teaching model in a physical assessment course. Multiple simulation education was applied to the physical assessment teaching model with the use of information technology. This teaching model was first built in 2015 and we continuously refined, compiled and implemented the model and teaching materials for two years. By 2017, a valid teaching model was finalized. The effects were evaluated with the concept of outcome-based education and the Miller's pyramid of clinical competence. Undergraduate nursing students participated in the implementation of the finalized model in 2017 in a university in northern Taiwan. Both qualitative and quantitative approaches were used to examine the nursing students' learning outcome of the physical assessment teaching model. The learning outcome was also examined by a set of objective structured clinical examination (OSCE). Taking Miller's pyramid of clinical competence as backbone, an innovative educational model of physical assessment was developed. This is a sustainable and replicable model for nurse educators to apply to cultivate nursing students with physical assessment competences with respect and caring attitudes.