Objectives: The Ministry of Health and Welfare has recently drafted a bill entitled “Medical Incident Prevention and Dispute Resolution,” which seeks to incorporate the strategy and content of open disclosure practices that are in place in Europe and the United States. In the event that Taiwan implements this bill, the potential obstacles that may be encountered should be investigated as well as the coordinated set of measures that the bill will require. Methods: In addition to referring to the experience of other countries practicing open disclosure, this study employed the Delphi method to collect opinions from 16 domestic experts on the question of medical disputes. The aim was to analyze the obstacles and evaluate the coordinated set of measures needed to implement open disclosure in Taiwan. Results: After 3 rounds of questionnaires, the experts surveyed proposed 38 recommendations addressing the barriers medical institutions may face when implementing open disclosure. High consensus was reached on 30 of these recommendations. Additionally, 41 recommendations were offered regarding a coordinated set of measures for implementing open disclosure, with high consensus achieved for 34. Conclusions: The recommendations obtained through this research include the following. First, when medical institutions deal with adverse medical events, the tendency of management to conceal and blame individuals should cease. Instead, solutions should be implemented to establish mechanisms and bring changes to the organizational culture to ensure the truth is preserved. Second, improvements are warranted in terms of the hostile social culture and legal system. A friendly environment should be created to ensure that medical disputes are resolved amicably. Third, efforts should be made to foster mature open disclosure behaviors and enhance the confidence of medical staff through education and training.