半導體場效式生化感測元件

Semiconductor-Based Field-Effect Device for In-Vitro Biomolecular Sensing

近來對於醫療照護的需求與日俱增，各種新穎醫療照護技術的發展成為現今醫療科技的主軸。相關新式生物分子檢測中，免標記半導體場效感測元件（label-free semiconductor fi eld-effect sensor device）為最具吸引性的技術之一。其快速、即時（real-time）、高專一性與靈敏性等優點，搭配醫學與半導體技術的演進，於早期診斷之定點照護（point-of-care）與個人化醫學的實現上，提供了一個潛力極佳的平台技術。本文即針對免標誌半導體場效感測元件進行介紹，期能提供基本認識與進一步發展的基礎。 Within the demands of medical technologies, in-vitro diagnosis is important because it helps to physicians to determine diseases. As a consequence, various kinds of in-vitro diagnosis technologies have been proposed and evaluated. In different kinds of in-vitro diagnosis, label-free semiconductor field-effect sensing devices obtain attentions because of its characteristics of real-time, high sensitivity/selectivity, and low cost. These characteristics offer great potentials in the developing personal healthcare technologies. Therefore, this article aims to review recent developments in label-free fi eld-effect biomolecular sensing devices and promote fundamental knowledge of related technologies.