利用氣相層析法同時分離鑑別Pheniramine maleate、Chlorpheniramine maleate、Carbinoxamine maleate、Pyrilamine maleate及Caffeine anhydrouss等成分

SIMULTANEOUS DETERMINATION OF PHENIRAMINE MALEATE, CHLORPHENIRAMINE MALEATE, CARBINOXAMINE MALEATE, PYRILAMINE MALEATE AND CAFFEINE ANHYDROUS BY GAS LIQUID CHROMATOGRAPHY

綜合感冒製劑中，常加入pheniraminemaleate，Chlorpheniramine maleate，carbinoxamine maleate，pyrilamine maleate等成分，並常與caffeine併用，利用氣相層析法可同時將上述5種成分分離定性，其分離效果良好，簡單迅速而精確。其層析條件為：玻璃分離營6'／x〞x2mm，填V－17onChromosorbW，80～100mesh溫度230°C，檢出器：FID。 Pheniramine Maleate, Chlorpheinramine Maleate, Carbinoxamine Maleate and Pyrilamine Maleate are antihistamines useful for allergy and cold, Caffeine anhydrous is CNS exciting agent The simultaneous determination of these ingredients in the cough and cold Pharmaceuticals has been developed by gas liquid chromatography, Chromatographic separatiðn was performed on a 6' x 4' x 2 mm glass column, which was filled with 3% OV-17 on chromosorb W, 80-100 mesh, and connected to a flame ion detector at 260°C. This method has been applied satisfactorily in Syrups, Tablets and Capsules.