刺五加（Eleutherococcus Senticosus (Rupr. et Maxim.) Maxim.）萃取物對鎘中毒小鼠之影響   全文下載

The Effect of Eleutherococcus Senticosus (Rupr. et Maxim.) Maxim. Extract on Cadmium-Induced Toxicity in Mice

本研究分析刺五加（Eleutherococcus Senticosus (Rupr. et Maxim.) Maxim.）乙醇萃取物對腹腔注射氯化鎘溶液0.05 LD50誘導中毒小鼠的長期（6週）影響。本實驗採用白色實驗室小鼠，兩組小鼠分別注射刺五加乙醇萃取物0.05和0.10 LD50。以原子吸光光譜儀檢測血液、腎臟、肝臟、脾臟、心臟及骨骼肌中的鎘濃度，長期注射刺五加乙醇萃取物及氯化鎘會顯著增加實驗小鼠脾臟、骨骼肌、血液、腎臟和肝臟的鎘濃度。刺五加也降低鎘引起的肝細胞有絲分裂活性。

The present study analyzed the effects of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract on long-term (6-week) intoxication induced by intraperitoneal injections of 0.05 LD50 of cadmium chloride solution. The experiments were performed with white laboratory mice. Two groups of mice were injected with ethanol extract of E. senticosus: 0.05 LD50 and 0.10 LD50. Cadmium concentrations were investigated in blood, kidney, liver, spleen, heart, and skeletal muscle by atomic absorption spectroscopy. Long-term injections of Eleutherococcus senticosus (Rupr. et Maxim.) Maxim. ethanol extract combined with CdCl2 led to significant increase of cadmium concentrations in the spleen, skeletal muscle, blood, kidney and liver of experimental mice. E. senticosus also decreased the mitotic activity of liver cells induced by cadmium.