製備電位差傳感器應用於藥物及生體液中 Naltrexone HCl 含量測定   全文下載

Preparation of a Naltrexone HCl Potentiometric Sensor and Its Application to Pharmaceutical Analysis and Drug Determination in Biological Fluids

本研究製備一新的離子選擇性電極，用於naltrexone HCl藥物分析及生體液中藥物含量測定，採直接電位法，不須複雜的前處理和萃取。PVC薄膜電極原位浸泡於1 × 10-3 M naltrexone溶液中，會產生naltrexone與四苯硼鈉（NaTPB）複合物。濃度範圍介於1 × 10-5及1 × 10-3 M時，傳感器呈現快速，可再現及線性能斯特反應，偵測極限為5 × 10-6 M。薄膜傳感器成功的應用於naltrexone膠囊及尿液、血漿樣品中藥物含量測定。

A novel ion selective electrode is fabricated for naltrexone HCl and used in pharmaceutical analysis and drug determination in biological fluids without complicated pretreatments and extractions, using direct potentiometry. The naltrexone complex with sodium tetraphenyl borate (NaTPB) is obtained by in situ soaking PVC membrane electrode in an 1 × 10-3 M naltrexone solution. The sensor exhibited fast, reproducible and linear sub-Nernstian response over concentration range of 1 × 10-5 - 1 × 10-3 M with a detection limit of 5 × 10-6 M. The membrane sensor was successfully applied to the determination of naltrexone in capsules as well as for its determination in urine and plasma samples.