二苯甲醯基甲烷對雌性小鼠脂肪組織質量、血液中脂質及性荷爾蒙含量之影響   全文下載

Dibenzoylmethane Altered Adipose Mass, Serum Lipid and Sex Steroid Hormone in Female Mice

二苯甲醯基甲烷（DBM），為一薑黃素之 β-二酮類結構類似物，有研究指出DBM可以有效抑制小鼠乳腺腫瘤，且具有化學癌症預防作用。從本實驗室先前的體內及體外試驗研究中均顯示DBM有調控雌激素的作用，本研究擬進一步探討DBM對兩種不同小鼠活體模式（CD-1及Sencar小鼠）中對脂質代謝調控的影響。經由量測小鼠活體中脂質代謝相關之生物活性指標及中間代謝產物，發現餵食含1% DBM之小鼠，其皮下脂肪重及三酸甘油脂均有顯著性的降低。另外對於CD-1及出生約55天時（動情周期）之Sencar小鼠，血液中雌二醇量、子宮重量及乳腺重量均有顯著降低。研究結果發現血液中雌二醇及三酸甘油脂同時呈現顯著性的減少可解釋DBM抑制小鼠乳腺腫瘤可能在為脂質代謝過程中扮演調控的角色。

Dibenzoylmethane (DBM), a β-diketone structural analogue of curcumin, has been reported to exhibit anti-tumorigenic and chemopreventive activities in mouse mammary tumorigenesis. Our previous study indicated that DBM modulates estrogenic action both in vitro and in vivo. In this report, the potential role of DBM as modulator of lipid metabolism in two mouse models was inves-tigated. Several biomarkers and intermediate metabolites related to lipid consumption were measured. The results indicated that the parametrial fat pad weight, the level of triglyceride in both CD-1 and Sencar mice fed with 1% DBM, was remarkably reduced. In addition, the estradiol level, uterus and mammary gland weights were significantly decreased in CD-1 and young Sencar mice at 55 days of age (during the estrous phase of estrous cycle). The reduction of both estradiol level and triglyceride in serum would explain the inhibitory effect of DBM on mammary tumorigenesis as a modulator in dietary lipid metabolism.