新型電位膜傳感器分析製劑及尿液中 Citalopram   全文下載

Citalopram Analysis in Formulation and Urine by a Novel Citalopram Potentiometric Membrane Sensor

Citalopram 是一種治療情緒失調的抗憂鬱症藥物。本研究介紹一種以聚氯乙烯（PVC）膜傳感器為基礎的離子對設計，用以檢測 citalopram。有關膜的製備，以 citalopram-tetraphenyl borate 離子對為電學原料。其他塑化劑如 dibutyl phthalate （DBP）、acetophenon （AP）、nitrobenzene （NB） 及 nitrophenyloctyl ether （o-NPOE） 也都同時納入研究。經由一系列的實驗，30%PVC、66% DBP 及 4% 離子對組成的膜，可達最佳電極性能。citalopram濃度範圍 1×10-5 至 1×10-2 M，pH 介於 3.0-5.5 時，電極展現快速（~5 s）、穩定能斯特反應（58.6 ± 0.3 mV/decade）。本研究之確效顯示，傳感器方法簡單、精確且可應用於 HPLC，適合用於分析製劑及尿液中 citalopram hydrobromide。

Citalopram is an antidepressant drug used to treat depression associated with mood disorders. This research introduces the design of an ion-pair based polyvinylchloride (PVC) membrane sensor for the citalopram determination based on theoretical investigations. For the membrane preparation, citalopram-tetraphenyl borate ion-pair was employed as an electroactive material in the PVC membrane. In parallel, several plasticizers were studied, i.e. dibutyl phthalate (DBP), acetophenon (AP), nitrobenzene (NB) and nitrophenyloctyl ether (o-NPOE). After a series of experiments, the best electrode performance was accomplished with a membrane composition of 30% PVC, 66% DBP, and 4% ion-pair. This electrode illustrated a fast (~5 s), stable and Nernstian response (58.6 ± 0.3 mV/decade) across a relatively wide citalopram concentration range 1×10-5 to 1×10-2 M and in the pH range of 3.0-5.5. Validation of the method showed suitability of the sensors for the quality control analysis of citalopram hydrobromide in pharmaceutical formulation and urine. The proposed method was simple, accurate and precise and can be used as a detector for HPLC.