口服沙棘果萃取物可改善 Haloperidol 引發之行為缺陷並增加腦血清素代謝   全文下載

Oral Supplementation of Sea Buckthorn (Hippophae Rhamnoides L. Spp. Turkestanica) Fruit Extract Modifies Haloperidol Induced Behavioral Deficits and Increases Brain Serotonin Metabolism

沙棘果種子及漿果萃取之果泥和油（萃取物），傳統上用於治療精神疾病。精神分裂症是一種嚴重的慢性精神病，約有 1% 人口罹此症狀，第一代抗精神病藥物 chlorpromazine 與 haloperidol 雖廣泛地用於治療精神分裂症，但會產生錐體外徑副作用（EPS）。本實驗研究服用 haloperidol 之大鼠，口服沙棘果萃取物（HRL-FE）後對行為缺陷之影響及大腦血清素代謝變化。先依體重給予大鼠 3.0 mg/kg 劑量之 haloperidol，一天二次（上午 09:00-09:30 及下午 05:00-05:30），連續餵食二週。結果顯示，當再給予口服 HRL-FE（4.0 mg/kg body weight）二週後，大鼠行為有顯著性差異（p<0.01），於籠裡或開放性場所活動力均增加；重複餵食 haloperidol 會顯著降低大鼠腦色胺酸及血清素代謝，此些降低反應，經餵食 HRL-FE（4.0 mg/kg body weight）後可逆轉，這些數據顯示 HRL-FE 可改善 haloperidol 引發之行為缺陷，並可擴及為精神分裂症傳統治療之營養療法。

Pulp and oils (fruit extract) from Sea Buckthorn (Hippophae rhamnoides L. spp. Turkestanica) (HRL) seeds and berries have been traditionally used in the treatment of different clinical and psychotic disorders and have significant implication in contemporary medicinal therapy. Schizophrenia is a chronic severe mental illness that affects approximately 1% of the population. Although the first generation of antipsychotic drugs such as chlorpromazine and haloperidol are widely prescribed for the treatment of schizophrenia, their beneficial effects are accompanied by extrapyramidal side effects (EPS). The present study was designed to investigate the effects of oral supplementation of HRL fruit extract (HRL-FE) on behavioral deficits and changes in brain serotonin (5- hydroxytryptamine; 5-HT) metabolism in rats administered with haloperidol repeatedly (two times a day at 09:00-09:30 A.M. and 05:00-05:30 P.M. at dose of 3.0 mg/kg body weight for two weeks. Results revealed that after two weeks of oral administration of HRL-FE (4.0 mg/kg body weight), rats exhibited significant (p<0.01) increases in locomotor activity in home cages and exploratory activity in open field arena. Repeated haloperidol treatment significantly (p<0.01) decreased brain tryptophan (TRP) and 5-HT and these decreases were reversed by 4.0 mg/kg body weight HRL-FE. These data suggest that HRL-FE plays a modifying role against the haloperidol induced behavioral deficits and could further extend as a nutritive therapy to conventional antipsychotic treatment in schizophrenia.