中草藥與膳食補充品中呲咯里西啶生物鹼的測定及其肝毒性和致癌性   全文下載

Detection, Hepatotoxicity, and Tumorigenicity of Pyrrolizidine Alkaloids in Chinese Herbal Plants and Herbal Dietary Supplements

1994 年美國國會通過膳食補充品健康和教育法案（the dietary Supplement health and education act）之後，膳食補充品的消費極速成長。為了保障消費大眾的健康，用於製造膳食補充品的中草藥，其品質和安全性，必需監控。目前一般中草藥及草藥膳食補充品是否含有肝毒性及致癌性成份，所知有限。呲咯里西啶生物鹼存在於六千多種植物中，已知很多具有肝毒性及致癌性。某些中草藥及膳食補充品被證實含有此類生物鹼。本文簡介在中草藥和商品中，含此類生物鹼的化學鑑定方法，及其肝毒性及致癌性的代謝活化過程。本文並對未來研究此類生物鹼的方向提供建議。

Since the U.S. Congress passed the Dietary Supplement Health and Education Act (DSHEA) in 1994, herbal products, including herbal dietary supplements, represent the fastest growing segment of the vitamin, mineral supplements, and herbal products industry. To ensure consumer health protection, the quality and safety of raw herbal plants used for dietary supplement preparations have to be determined. To date, safety issues concerning the hepatotoxic and tumorigenic ingredients in many raw herbs and herbal dietary products are quite limited. Pyrrolizidine alkaloids are a class of hepatotoxic and tumorigenic phytochemicals present in more than 6000 plants and have been detected in herbal plants and dietary supplements. In this review, the human exposure, metabolic activation leading to hepatototoxicity and tumorigenicity of the pyrrolizidine alkaloid-containing Chinese herbal plants, and analytical methods used to identify and quantify pyrrolizidine alkaloids in herbal plants and commercial samples are discussed. Suggestions for future research are provided.