以高效能液相層析法分析馬兜鈴屬植物所含的馬兜鈴酸及馬兜鈴內醯胺衍生物   全文下載

Analysis of the Analogues of Aristolochic Acid and Aristolactam in the Plant of Aristolochia Genus by HPLC

逆相高效能液相層析法應用於傳統中藥中馬兜鈴酸（AA）及馬兜鈴內醯胺（AL）衍生物之定性定量研究上。同名異物之中藥材如粉防己（Stephania tetrandra）與廣防己（Aristolochia fanchi ）、川木通（Clematis armandii）與關木通（A. manshuriensis）等可簡易地利用此方法區分。本篇文章針對12種馬兜鈴屬植物（A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A .foveolata, A. contorta, A. trilobata and A. odoratissima）所含之AAs及ALs做定量分析。研究結果提供馬兜鈴屬植物之指紋圖譜，避免傳統中藥製造時的誤用。"

A facile reversed-phase HPLC method for the analysis of aristolochic acid (AA) and aristolactam (AL) analogues was developed and used for the quantitative determination and quality control of the traditional Chinese medicine. Homonymic Chinese crude drugs such as Stephania tetrandra (粉防己) and Aristolochia fanchi (廣防己), Clematis armandii (川木通) and A. manshuriensis (關木通) can be easily identified by this method. The quantitative determination of AAs and ALs in 12 species of Aristolochia (A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A. foveolata, A. contorta, A. trilobata and A. odoratissima) has been investigated. The chromatograms obtained in this study can serve as fingerprints to identify plant species in the Aristolochia genus, thus avoiding incorrect identification of herbal ingredients in manufacturing traditional Chinese medicine. 逆相高效能液相層析法應用於傳統中藥中馬兜鈴酸（AA）及馬兜鈴內醯胺（AL）衍生物之定性定量研究上。同名異物之中藥材如粉防己（Stephania tetrandra）與廣防己（Aristolochia fanchi ）、川木通（Clematis armandii）與關木通（A. manshuriensis）等可簡易地利用此方法區分。本篇文章針對12種馬兜鈴屬植物（A. elegans, A. zollingeriana, A. cucurbitifolia, A. mollis, A. kaempferi, A. shimadii, A. heterophylla, A. debilis, A .foveolata, A. contorta, A. trilobata and A. odoratissima）所含之AAs及ALs做定量分析。研究結果提供馬兜鈴屬植物之指紋圖譜，避免傳統中藥製造時的誤用。