回顧聚離子感測電極在藥學領域之應用   全文下載

Applications of Polyion-sensitive Electrodes to Pharmaceutical Domain: a Mini-review

本文回顧聚離子感測電極應用於藥學的最新發展，文中論述此類電極感測器之作用原理及新用途，包括：（一）利用魚精蛋白或聚精胺酸測定肝素（抗凝劑）及多硫酸聚戊醣（骨關節炎治療藥）的電位滴定法；（二）利用魚精蛋白作為受質的血栓溶解酵素活性分析法。

Recent development in the pharmaceutical applications of polyion-sensitive electrodes (PSEs) is reviewed. The general electrochemical principle governing the potentiometric response of such polymer membrane-based devices is summarized and applications for the use of these novel sensors are detailed. These new applications include methods to quantitate the anticoagulant heparin and pentosan polysulfate, an anti-osteoarthritis drug, via titration with polycationic protamine or polyarginine, as well as selective assay on fibrinolytic enzymes (e.g., plasminogen activators and plasminogen) using protamine as the substrate based on potentiometric polyion detection. 本文回顧聚離子感測電極應用於藥學的最新發展，文中論述此類電極感測器之作用原理及新用途，包括：（一）利用魚精蛋白或聚精胺酸測定肝素（抗凝劑）及多硫酸聚戊醣（骨關節炎治療藥）的電位滴定法；（二）利用魚精蛋白作為受質的血栓溶解酵素活性分析法。