肝細胞癌患者腫瘤與非腫瘤組織中四種金屬離子濃度之測定   全文下載

The Concentrations of Four Metal Ions in Tumor and Non-tumor Regions of Livers from Patients with Hepatocellular Carcinoma

本篇利用感應耦合電漿原子發射光譜法來制定肝細胞癌組織中四種金屬離子：鋅、錳、鐵、銅之濃度，分析18位原發性肝細胞癌患者經開刀所取出之腫瘤組織，並以同患者之非腫瘤組織為對照，發現腫瘤組織中鋅、錳離子之含量較非腫瘤組織低（P<0.05及P<0.0005），推測其原因可能與腫瘤組織中以鋅，錳離子為輔因子之某些葡萄糖代謝酵素，如lactate dehydrogenase, glucokinase, pyruvate dehydrogenase之活性降低有關，而鐵和銅離子則在兩區域間無統計意義之差別。"

The concentrations of Zn, Mn, Fe, Cu in tumor and non-tumor regions from human hepatocellular carcinoma (HCC) specimens were measured by ICP-AES. Resected liver tissues from eighteen patients with HCC were collected for this study. Lower zinc and manganese ion concentrations were demonstrated in tumor regions (Zn+2,P <0.05;Mn+2,P <0.0005). It might indicate lower activities of some glucose metabolic enzymes in HCC tumor tissues, such as lactate dehydrogenase, glucokinase and pyruvate dehydrogenase. No significant differences in the concentrations of iron (P=0.78) and copper (P=0.12) ions between tumor and non-tumor regions were found.