高壓液相層析法定量口服鎮痛錠劑成分咖啡鹼、乙氧基苄醯胺及異丙安替比林   全文下載

Simultaneous Quantitation of Caffeine, Ethoxybenzamide and Propyphenazone in Oral Analgesic Tablets by High-Pressure Liquid Chromatography

本報告敘述以柳醯胺（salicylamide）為內部標準，利用高壓液相層析法，以μbondapak C18層析柱及甲醇-乙?-3%醋酸（24 ： 16 ： 60）為移動相，進行市售口服鎮痛錠劑成分咖啡鹼（caffeine），乙氧基?醯胺（ethoxybenzamide）及異丙安替比林（propyphenazone）之定量分析。研究顯示本法為一簡單，快速且準確的方法。

A method for simultaneous quantitation of caffeine, ethoxybenzamide and propyphenazone is described. The method was based on reversed-phase high-pressure liquid chromatography with a mobile phase of methanol-acetonitrile-3% aqueous acetic acid solution (24 : 16 : 60, v/v). The compounds were well separated from each other by the propcedure, using salicylamide as internal standard. The method gave excellent results and provided a simple, rapid and accurate method for separation and quantitation of synthetic mixtures and commercial products.