| 英文摘要 |
Hyponatremia is a well-known adverse effect of antidepressants. It varies from mild to fatal in severity. Here, we report a case of a patient with severe hyponatremia after a two-day treatment with a selective serotonin reuptake inhibitor (SSRI). A 68-year-old married woman patient had the fi rst major depressive episode. She had a history of ingesting corrosive alkali liquid at age of 62 years. She was admitted to intensive care unit due to extensive injuries of the mucosa, submucosa and deep penetrating ulcers of esophagus and stomach. A feeding jejunostomy was done following esophagectomy and total gastrectomy. She was hospitalized for three times due to stenosis of the esophagus and repeated pneumonia. She also had several episodes of asymptomatic hyponatremia. She did not accept psychiatric treatment due to her self-imposed stigma. The patient visited another psychiatrist for another episode of depressive mood for one month in July 2017. She also suffered from lack of interest, anxiety, fatigability, insomnia, poor concentration, guilty thoughts, feeling of hopelessness, and suicidal ideations. Her body mass index (BMI) was 15.3 kg/m2 . Besides corrosive liquid induced physical complications, she did not have any systemic diseases. She visited outpatient clinic of thoracic surgery regularly for having feeding tube changed without taking any medications. She started to receive sertraline. The dose of sertraline was 25 mg in the fi rst day, and was adjusted to 50 mg in the second day. On the third day, she developed weakness, dyspnea, and lethargy, then she was brought to emergency department. |
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