老年期雙極症與思覺失調症病人的心電圖特徵比較研究

Differences in Electrocardiographic Findings between Oder Adult Patients with Bipolar Disorder and Schizophrenia

Objective: We intended to compare the standard 12-lead electrocardiogram (ECG) recordings in older patients with bipolar disorder (BD) and schizophrenia (SZ). Methods: We recruited 109 outpatients who were aged over 50 years and had a diagnosis of BD-I or SZ. A board-certifi ed cardiologist who was blinded to clinical information, analyzed the 12-lead ECG recordings. Clinical data were obtained using interview and chart review. Results: We recruited 44 patients with BD and 65 patients with SZ. We found that signifi cantly higher proportion of BD patients had ECG-defi ned left ventricular hypertrophy than that in SZ patients (13.6% vs. 3.1%, p < 0.05). In addition, patients with BD had signifi cantly higher diastolic blood pressure and body mass index on the day of the most recent psychiatric admission than did those with SZ. Conclusion: Patients with BD are at a greater risk of ECG-defi ned left ventricular hypertrophy which may link to the unfavorable psychopathological and pathophysiological outcomes of BD itself. 目的：雙極症與思覺失調症病人皆為心臟血管疾病之高風險族群，然目前仍缺少老年期雙極症與思覺失調症病人之十二導程心電圖特徵比較研究。方法：由心臟專科醫師判讀44位雙極症與65位思覺失調症病人之心電圖，精神專科醫師以會談與病歷回溯取得臨床資料。結果：13.6%之雙極症病人與3.1%之思覺失調症病人在心電圖上有左心室肥大之特徵（p<0.05），此外，雙極症病人於最近一次精神科住院有較高之身高體重指數及舒張壓。結論：雙極症病人較思覺失調症患者更易具有左心室肥大特徵，可能與雙極性疾患本身之精神病理生理機轉有關。

目的：雙極症與思覺失調症病人皆為心臟血管疾病之高風險族群，然目前仍缺少老年期雙極症與思覺失調症病人之十二導程心電圖特徵比較研究。方法：由心臟專科醫師判讀44位雙極症與65位思覺失調症病人之心電圖，精神專科醫師以會談與病歷回溯取得臨床資料。結果：13.6%之雙極症病人與3.1%之思覺失調症病人在心電圖上有左心室肥大之特徵（p<0.05），此外，雙極症病人於最近一次精神科住院有較高之身高體重指數及舒張壓。結論：雙極症病人較思覺失調症患者更易具有左心室肥大特徵，可能與雙極性疾患本身之精神病理生理機轉有關。