Recently, every region is committed to the industrialization of special resources, and makes them as local specialty products or services for booming of local economy, creation of employment opportunities, and expansion of regional labor market. It has become an important approach of regional development. The development and application of information technology has a critical impact on the currently local upgrading and transformation, and thus many regions actively promote smart city. It
makes the development of regional characteristics into new era of technicalization. This paper selects successful examples such as the smart city of Riverside City, Taipei City, Tokushima ken and Kagawa ken, and the ecological island of Penghu, which have a high international reputation. The study explores how these cases develop the local speciality via high tech to find out the essential elements of local economic development strategies. As a result, this study categorizes four essential elements which are leadership and integration, flexible innovation, external supports and human development.