KAMARO’AN is a Makotaay’s brand, which was achieved through a collaboration project involved a design team from a university and artisans form Hualien's Makota'ay Village. The project exemplifies that design profession can contribute to the establishment of a community business in a sustainable and commercially viable way. To understand the entrepreneurial activities for building a profitable community business, this study adopted a practice-led research to understand the inquiry. Design knowledge is inherent in the activity of designing, gained by engaging in and reflecting on activities through the design process. Thus, participating in the project allows us to obtain the experiential knowledge and elicit reflection on the conducted project. According to the experience in conducting the project “KAMARO’AN”, this paper outlines the activities we carried out to establish a feasible value chain, including design creativity generated from the co-creation of the design team and Makotaay’s artisans, flexible manufacturing methods combining the tribal hand production and modern methods, and marketing/distribution activities through the use of internal and external resources. Further discussions and suggestions on how to build a growing community brand and design-led start-ups are presented at the end of this paper.