| 中文摘要 |
背景：分析多發性肌炎和皮肌炎病患臨床表現與抗Jo-1抗體之相關性。方法：我們收集長庚醫院2000至2007年之間151位多發性肌炎和皮肌炎病患病歷做回顧性分析。結果：於151位病患中，有80位有做抗Jo-1抗體；於單一變數分析中發現間質性肺病（p=0.011）、心臟侵犯（p<0.001）、高血壓（p=0.045）及吞嚥困難（p=0.005）有顯著差異；在控制性別後,以多變數回歸分析顯示出現抗Jo-1抗體病患合併間質性肺病（勝算比：7.49, 95%信賴區間：1.12-49.91, p=0.037）及心臟侵犯（勝算比： 9.39, 95%信賴區間：1.34-165.83, p=0.024）比起沒有抗Jo-1抗體病患有達到統計學的差異性；而以存活分析比較出現抗Jo-1抗體病患及沒有抗Jo-1抗體病患並未達到明顯差異（p=0.201）。結論：帶有抗Jo-1抗體病患與出現間質性肺病和心臟侵犯的臨床症狀有顯著的相關性；但出現抗Jo-1抗體病患對存活沒有明顯的影響。 |
| 英文摘要 |
Background: Polymyositis and dermatomyositis are idiopathic inflammatory myopathies and anti-Jo-1 is the most common autoantibody found in inflammatory myositis patients. We aimed to demonstrate clinical symptoms and signs related to anti-Jo-1 antibody in patients with polymoyositis and dermatomyositis. Materials and Methods: We retrospectively reviewed medical records of 151 patients with polymoyositis and dermatomyositis in Chang Gung Memorial Hospital from 2000 to 2007. Results: Eighty (53%) of 151 patients had identified anti-Jo-1 antibody. Interstitial lung disease, cardiac involvement, hypertension, and dysphagia were associated with the presence of anti-Jo-1 antibody according to univariate analysis (p=0.011, <0.001, 0.045, and 0.005, respectively). Multivariate analysis, after adjusting for gender, showed that only interstitial lung disease (odds ratio = 7.49, 95% CI = 1.12-49.91, p=0.037) and cardiac involvement (odds ratio = 9.39, 95% CI = 1.34-165.83, p=0.024) were associated with the presence of anti-Jo-1 antibody. Kaplan-Meier survival analysis was not significantly lower in anti-Jo-1 positive patients than that in those without anti-Jo-1 antibody (p=0.201). Conclusion: This study highlights the clinical symptoms and signs related to anti-Jo-1 antibody in polymoyositis and dermatomyositis. Clinical presentation of interstitial lung disease and cardiac involvement were significantly associated with the presence of anti-Jo-1 antibody although anti-Jo-1 antibody had no influence on survival. |
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