慢性精神分裂病患在抗精神藥物作用下異常性的淋巴球反應：可溶性第二介白質接受體濃度的增加

Aberrant Lymphocyte Activation in Chronic Treated Schizophrenics: Increased Serum Interleukin-2 Receptors

為了能暸解慢性之精神分裂病患有關異常的淋巴球反應，本研究之對象為21位慢性之精神分裂病患。在淋巴球反應方面是經由酵素連接免疫吸附測定法（ELISA）的方式來測定血清中可溶性第二介白質接受體之濃度。在為期1個月的抗精神藥物治療下，其血清中的可溶性第二介白質接受體的濃度（1614.2 ± 154.2 U/ml）遠高於急性發作時（927.5 ± 124.6 U/ml）及健康對照組（891.8 ± 58.7 U/ml）之濃度並且具有統計學上的意義（F=17.5; df=2,17; p

To determine aberrant lymphocyte activation in chronic schizophrenia, twenty-one cases were enrolled in this study. Lymphocyte activation was evaluated by the levels of soluble interleukin-2 receptors (sIL-2R) which. were determined by ELISA (enzyme linked immunosorbent assay). After one-month's neuroleptics treatment, increased serum levels (1614.2 ± 154.2 U/ml) of sIL-2R were statistically different (F=17.5; df=2,17; p<0.0001) to these of acute episodes (927.5 ± 124.6 U/ml) and normal controls (891.8 ± 58.7 U/ml). Nevertheless, there were no significant difference (p=0.80) of serum levels between acute episodes and normal controls in spite of higher levels of the former. On the other hand, these change of levels of sIL-2R showed no relation to the improvement of clinical status [either positive scale (r=0.41; p=0.72) or negative scale (r=0.18; p=0.46)]. The present study suggested the change of sIL-2R in serum levels could not be a predictor of the improvement of clinical status and the partial activation of lymphocyte may occur in Chinese chronic schizophrenic patients who were in acute episodes. Furthermore, there were significant stimulating effect of the neuroleptics on sIL-2R concentrations.