台灣地區的類肉瘤：臨床觀查

Sarcoidosis in Taiwan: Clinical Survey

類肉瘤病是多系統性原因不明的肉芽腫疾病，通常好患兩側肺門淋巴病變及肺部侵潤，在台灣尚未有此方面分析報告。我們收集近十年在三軍總醫院診斷為類肉瘤病的病例做分析。於病灶侵犯部位淋巴結做切片，病理組織結果為非乾酪性肉芽腫。共有十二病例，男女比例為2比1，診斷的平均年齡38歲（範周20～61歲），臨床表徵為肺部症狀75%，琳巴病變83.3%，皮膚症狀41.6%，眼睛症狀25%，神經症狀8%，血液症狀33.3%，內分泌代謝、心臟、及肝臟症狀皆為8%。而腎臟及關節系統方面則較少侵犯。以類固醇治療及長期追蹤（平均31.8月），預後良好。雖然收集為例不多，但結果與國外研究類似，故可表示在台灣地區類肉瘤病的臨床表現情形。

Sarcoidosis is a systemic granulomatous disorder of unknown etiology, most present with bilateral hilar lymphadenopathy and pulmonary infiltration. However, other distinct manifestations may also happen. In this study, we analyzed the clinical pictures, therapeutic courses, and outcomes of twelve sarcoidosis patients who were admitted to Tri-Service General Hospital form 1988 to 1998. The diagnosis of sarcoidosis was proven by tissue biopsies. The ratio of male to female was 2 to 1. The range of age was from 20 to 61 year-old with a mean of 38 year-old. The manifestations included pulmonary symptoms 75%, lymphadenopathy 83.3%, dermatopathy 41.6%, oculopathy 25%, neuropathy 12%, hematologic abnormalities 33.3%, endocrine/metabolism, hepatic and cardiac abnormalities 8%. Other manifestations such as renal and musculoskeletal system were not evaluated. The prognosis of sarcoidosis is good. Steroid is the drug of choice to sarcoidosis. The therapeutic durations were followed from 2 to 114 months, with a mean of 31.8 months. Our studies showed the clinical manifestations, therapeutic courses and outcomes of sarcoidosis in Taiwan were similar to western countries.