糖尿病與前期病患神經性疼痛之危險因子

Risk Factors for Neuropathic Pain in Diabetes and Prediabetes

糖尿病是一個日益增加的慢性疾病，約有三分之一的患者深受神經病變所苦，特別是疼痛。回顧文獻，神經性疼痛在糖尿病患及其前期患者（包含血糖不耐Impaired Glucose Tolerance，及空腹血糖障礙Impaired Fasting Glucose，相對正常族群皆有統計意義上的差異。而且除血糖外，神經性疼痛的相關危險因子亦包括年齡、體重、腰圍、週邊血管病變和缺乏運動；而在前期患者中，血糖不耐患者又比空腹血糖障礙患者，有更高的比例有神經性疼痛。另外研究也顯示，大血管病變（心肌梗塞存活患者的研究）也是神經性疼痛的危險因子。

Diabetes mellitus is one of the most common chronic diseases worldwide. Eight to 26% of the diabetic population has been reported to be affected by neuropathic pain, which may exert a substantial impact on the quality of life by interfering with daily functioning and enjoyment of life. The studies revealed in general subjects (N=393), age, weight, peripheral arterial disease (PAD), and diabetes were risk factors significantly associated with neuropathic pain, while in the diabetic group, these factors were age, weight, and PAD. In study for survivors of myocardial infarction (MI) (n = 426), prevalence of neuropathic pain was even higher and the risk factors were age, waist circumference, peripheral arterial disease (PAD), and diabetes; while in the diabetic group it was waist circumference, physical activity, and PAD.