論回顧揮發性吸入麻醉藥在分子細胞網絡層次上中央神經元作用點之效應

Channel Site Effects of Volatile Anesthetics on Molecular Network Levels in the Central Neuron

揮發性吸入麻醉藥的全麻作用在中央神經元的研究已成為全麻械制研究的重點。但限於中樞神經系統的複雜性和傳統研究的局限性，至今未能篩選到理想的特異性全麻作用位點，在整體動物麻醉中得到確禮。近年來隨著新的研究方法和策略的應用，揮發性吸入麻醉藥的中樞作用位點，以及揮發性吸入麻醉藥對中樞神經傳導和離子通道蛋白功能的研究，均有了許多重要的成果。特別是目前發展的對揮發性吸入麻醉藥敏感性相關基因的研究，並已在揮發性吸入麻醉藥全麻敏感基因的定位、克隆及功能鑑定方面有了重要進展，初步顯示出其在全麻機制研究中重要的價值。但目前發現揮發性吸入麻醉藥的全麻敏感基因數量尚少，並且在各種生物模型中篩選到的敏感基因差異較大。進一步探索敏感性和特異性較高的全麻相關基因並尋求其共遍性，將是將來研究的主要方向。同時由於分子遺傳學的迅速發展、人類基因組計畫的成功實施、以及基因晶片的研製開發都將促進麻醉的研究發展。

The action of volatile anesthetics on their anesthetic target sites has become the focus of recent general anesthesia mechanism research. However, due to the restriction of the complexity of the central nervous system and also former traditional methods, it is difficult to select a specific volatile anesthetics action site and therefore, the effects of a specific volatile anesthetics action site have not been completely proven. Recently, based on the development of new methodologies accompanied by new strategies, the mechanisms of the action of volatile anesthetics on the central nervous system have been widely discussed. Previous studies have illustrated that volatile anesthetics may exert their effects on nerve impulses and influence the function of ion channel proteins. However, little information about the localization, clone, and function of the general anesthesia-sensitive gene has been reported. This review focuses on the exploration of the molecular mechanisms of volatile anesthetics on their anesthetic target sites.