針刺內關穴前後心率變異度及血液流體力學之變化

Heart rate variability analysis of Acupuncture

目的：藉由心率變異度的分析方法，評估針刺內關穴（P6）是否能提升副交感神經的活性。方法：三十二名針刺組以及三十一名對照組參與本研究，比較針刺組與對照組之間血液流體力學及心率變異度各項指標間的差異，進一步比較針刺P6前、後血液流體力學與心率變異度的變化。心電圖訊號的取樣頻率為200赫茲，高頻功率比（高頻功率／總功率）為副交感神經活性的指標，低頻功率比（低頻功率／總功率）為交感與副交感神經共同調控的指標。結果：針刺P6之後，收縮壓明顯低於對照組，心跳速率下降，心跳間期、心跳間期標準偏差、 心跳間期變異係數反而上升。高頻功率比從針刺前的27.1±13.2 nu上升到針刺後的37.6±14.1 nu，收縮壓從針刺前的124.9±14.0 mmHg下降到針刺後的116.0±11.2 mmHg。結論：針刺內關穴可以提升健康人副交感神經的活性，降低收縮壓，對於心血管系統可能有助益。

Objectives: To evaluated whether acupuncture at Neiguan point(P6)could improve the vagal modulation by using heart rate variability analysis. Methods: Thirty two P6 acupuncture group and thirty one No-treatment group were included in this study. We compared P6 acupuncture group and No-treatment group on hemodynamics and heart rate variability(HRV)measures. We further compared HRV and Hemodynamics after acupuncture at P6. The sampling frequency for ECG recording was 200 Hz. The normalized high-frequency power(nHFP=HFP/TP)was used as the index of vagal modulation: the normalized low-frequency power(nLFP=LFP/TP)as the index of sympathetic and vagal modulation. Results: We found that the systolic blood pressure(SBP)of P6 acupuncture group after acupuncture at P6 was significantly lower than that of No-treatment group. The heart rate(HR)of P6 acupuncture group after acupuncture at P6 was significantly decreased, in contrast, the mean RR intervals(mean RRI), the standard deviation and coefficient of variation of RR intervals(SDRR, CVRR)were all significantly increased. After acupuncture at P6, the nHFP increased significantly from 27.1±13.2 normalized unit(nu)before acupuncture at P6 to 37.6±14.1 nu after acupuncture at P6. After acupuncture at P6, the SBP decreased significantly from 124.9±14.0 mmHg before acupuncture at P6 to 116.0±11.2 mmHg after acupuncture at P6. Conclusion: We concluded that acupuncture at Neiguan point can increase the vagal modulation and decrease the SBP of the healthy subjects. It might be beneficial of the cardiovascular system.