Many studies have demonstrated that sleep disturbance is common among patients with Chronic Obstructive Pulmonary Disease (COPD) and can severely affect the nature of the COPD and the associated quality of life. Many studies also have explored these correlates of sleep disturbance; however, few studies have integrated and analyzed these correlates through using a systematic review. This paper reports a systematic review the objective of which was to review, synthesize, and evaluate studies about sleep disturbance in patients with COPD to identify factors important for sleep quality and serve as a reference for the clinical care and intervention of sleep disturbance in these patients. This study searched for literature in CINAHL, MEDLINE, the Cochrane Library, PubMed, the Index to Taiwan Periodical Literature System of the National Central Library, the National Digital Library of Theses and Dissertations in Taiwan, the Airiti Library, and Google Scholar. In these electronic databases, we sought published articles in Chinese and English prior to Dec 22, 2014 using the keywords of “COPD with insomnia,” “sleep quality,” “sleep disturbance,” “sleep deprivation,” “REM,” and “sleep quality improvement.” Fourteen studies met the inclusion criteria and were subjected to further analysis. The quality of each retrieved article was assessed using the STROBE checklist to examine the completeness and adequacy of the studies. This review found that over half of the patients with COPD in the selected studies had sleep disturbance, revealing that sleep quality might seriously affect daily life and need to be emphasized and improved. Significant correlates of sleep quality in patients with COPD included age, COPD severity, dyspnea, the number of acute exacerbation, lung function, depression, anxiety, and quality of life. In particular, among the above correlates, age, COPD severity, depression, anxiety, and quality of life were indicated in the majority of the selected studies. In summary, this review can serve as a reference for the clinical care of sleep disturbance in patients with COPD and provide direction for future empirical research in this field.