This research are focused on nine Health Care funds from 2009/1/1 to 2014/12/31 by method of rate of return, Sharpe ratio, β coefficient, VaR (value at risk) and investigated investment performance and value of risk by bootstrapping. Finally, used to Sharpe ratio and VaR made four quadrant to find out best choice of investments, offer investor suggestion of investment. The results show that Janus Global Life Sciences A has good performance by rate of return, Sharpe ratio and β coefficient but relatively high volatility risk of market; Invesco Global Health Sciences has bad performance but relatively low volatility risk of market. According to bootstrapping results that nine Health Care funds' optimum VaR model were relatively 95% VaR. Finally, nine Health Care funds made four quadrant analyses, excellent targets of investment were United Global Healthcare and Pictet-Health R.