Aripiprazole針對遲發性運動不能的治療：一位情感性思覺失調症病人的個案報告

The Treatment with Aripiprazole for Tardive Dyskinesia in a Patient with Schizoaffective Disorder

Tardive dyskinesia (TD) is an undesirable complication of long-term exposure to fi rst-generation (traditional) or second-generation (atypical) antipsychotic drugs. It is characterized by the lateonset of involuntary abnormal and repetitive movements. Although inconclusive, a cholinergic- dopaminergic imbalance has been proposed to be the main pathophysiology . The current treatment options for TD including amantadine, benzodiazepine, muscle relaxants, botulinum toxin injections and deep brain stimulation are insuffi cient and provide only a time-limited response. Aripiprazole which has the pharmacological mechanism of partial agonism at dopamine D2, D3, and 5-HT1A receptors , has been reported to be an alternative treatment for movement disorders, including Tourette’s syndrome and TD . Studies on the rôle of aripiprazole in alleviating or inducing TD have been inconclusive [3, 4]. Here, we report a case of a patient with onset of TD after aripiprazole withdrawal but improved after resuming aripiprazole.