發病中重鬱症病人的血糖

Fasting Serum Glucose Level in Unmedicated Patients with Major Depressive Disorder

目的：本研究目的為探討發病中重鬱症病人比起正常人是否代謝較差。方法：招募55位發病中重鬱症病人，25位已痊癒重鬱症病人，以及76位正常受試者。三組間彼此進行年齡、性別、身體質量指數、與日常生活壓力配對。收集血糖與其他代謝指標進行分析。結果：結果顯示3組間血糖存在組間差異，進一步分析發現發病中重鬱症病人的血糖較正常受試者顯著的高(p<0.05)，然而已痊癒重鬱症病人的血糖與其他兩組沒有顯著的差異。結論：此結果顯示不同重鬱症嚴重度下血糖可能會有不同。

Objectives:The study was aimed to explore whether unmedicated patients with major depressive disorder (MDD) have poorer metabolic profiles than healthy normal subjects.Methods:Fifty-five unmedicated MDD patients, 25 unmedi- cated euthymic patients with a history of MDD, and 76 healthy subjects were matched for age, sex, body mass index, and life stress, using recent life change questionnaire. We examined the subjects’ fasting glucose and other metabolic pro- files. Results:The results showed significant differences among MDD patients, euthymic patients and the control group in fasting serum glucose level (p< 0.05). Further analyzed data showed that the fasting serum glucose in MDD patients was significantly higher than that in the healthy controls (p< 0.05), and that no signifi- cant difference in fasting serum glucose was found between euthymic patients and the others two study groups. Conclusion:This result might suggest that fasting serum glucose level would be significantly different when the degrees of MDD severity are different.