失智症與兩性異同的關係

Sex Difference in Dementia

這篇綜說是來介紹男女性別，對罹患失智症的關係。作者在腦部功能、腦部構造、日本 男女失智病人的分佈資料、失智症病人在兩性的盛行率及發生率、女性為什麼容易罹患阿茲 海默失智症、神經類固醇及腦部持存假說等領域，回顧有關的文獻，來探討男女兩性罹患失 智症的危險因子。大體上研究資料顯示，女生比起男生有較高罹想患失智症的危險性（ 約 1.4 倍）。作者希望透過這篇綜論，能激發台灣讀者及研究者對這個題目的興趣，多注意失 智症兩性區別夠的議題，而在這題目上做些研究。

The overview is intended to do an introductory review on the research data related to the sex difference in dementia. The author reviews the topics of sex difference in brain function, and brain structure. Then he discusses the reason why female shows higher incidence of Alzheimer’s disease in the context of general population, prevalence and incidence of dementia, neurosteroids as well as brain reserve hypothesis. Basically, all research data have shown that female elderly carries higher risk of about 1.4 times in developing dementia compared to the male counterparts. With this overview, the author hopes that the contents of this overview can stimulate Taiwanese readers and researchers to pay more attention to the topic of sex differences in dementia, especially in Alzhiemer’s disease, and to do further research on this topic.