Quetiapine引發白血球減少症於曾有Clozapine引起之白血球減少症病史之

Leukopenia Induced by Quetiapine in a Patient with History of Clozapineinduced Leukopenia

目的：許多抗精神病藥物會引起血液學的異常。Quetiapine 和最容易引起血液惡病質症 的clozapine 一樣，均為dibenzothiazepine 的衍生物。個案報告為過去有clozapine 引起的 白血球減少症的病史，因使用quetiapine 後再度引起白血球減少症。個案報告：一位過去 曾經有clozapine 引起的白血球減少症的34 歲台藉女性精神分裂症病人，在經過quetiapine 治療之後，再度發生血液白血球減少症。在停用quetiapine 後，血液白血球數目回到正常 值。結論：臨床醫師應小心使用會引起血液惡病質症特性的藥物，特別是在使用在過去有藥 物引起血液惡病質症病史的病人上。

Objective: Many antipsychotic medications can cause hematological abnormalities. Quetiapine is a dibenzothiazepine derivative similar to clozapine, an antipsychotic agent which has the highest risk of causing blood dyscrasias. A case of quetiapine-induced leukopenia is described here in a patient who had a previous history of leukopenia induced by clozapine. Case Report: A 34-year-old Taiwanese woman patient with schizophrenia had a history of clozapine-induced leukopenia. She developed leukopenia again after her receiving quetiapine treatment. After quetiapine was discontinued, her white blood count was increased to a normal range. Conclusion: Physicians should be cautious of having potential hematological abnormalities before prescribing leukopenia-causing drugs, especially in patients with a history of drug-induced leukopenia.